On 16 December 1957 he was elected as the seventh Prime Minister of Pakistan. He held this post until 7 October 1958, when martial law was enforced for the first time in Pakistan's history by Iskander Mirza.
Noon was knighted in the 1933 New Year Honours List. He was further knighted with a KCIE in the 1937 Coronation Honours List and with a KCSI in October 1941. He was also appointed an Associate Officer of the Venerable Order of Saint John in December 1932.